The Road Ahead For Laser Therapy is Bright: Traumatic Brain Injury

Alzheimer’s Disease-related Pathologies:  Low Light Laser Therapy

Another exciting area neurological research is in Alzheimer’s disease-related pathologies. This is a relatively new area of research and is currently being done on the animal model but the early results are encouraging and could positively impact so many people.

The road ahead for Laser Therapy is bright!!

Photobiomodulation with Near-infrared Light Mitigates Alzheimer's Disease-related Pathology in Cerebral Cortex - Evidence from Two Transgenic Mouse Models

Purushothuman S1, Johnstone DM1, Nandasena C1, Mitrofanis J2, Stone J1.
Alzheimers Res Ther. 2014 3;6(1):2

INTRODUCTION: Previous work has demonstrated the efficacy of irradiating tissue with red to infrared light in mitigating cerebral pathology and degeneration in animal models of stroke, traumatic brain injury and Alzheimer's disease (AD). Using mouse models, we explored the neuroprotective effect of near infrared light (NIr) treatment, delivered at an age when substantial pathology is already present in the cerebral cortex.

METHODS: We studied two mouse models with AD-related pathologies: the K369I tau transgenic model (K3), engineered to develop neurofibrillary tangles, and the APPswe/PSEN1dE9 transgenic model (APP/PS1), engineered to develop amyloid plaques. Mice were treated with NIr 20 times over a four-week period and histochemistry was used to quantify AD-related pathological hallmarks and other markers of cell damage in the neocortex and hippocampus.

RESULTS: In the K3 mice, NIr treatment was associated with a reduction in hyperphosphorylated tau, neurofibrillary tangles and oxidative stress markers (4-hydroxynonenal and 8-hydroxy-2'-deoxyguanosine) to near wildtype levels in the neocortex and hippocampus, and with a restoration of expression of the mitochondrial marker cytochrome c oxidase in surviving neurons. In the APP/PS1 mice, NIr treatment was associated with a reduction in the size and number of amyloid-β plaques in the neocortex and hippocampus.

CONCLUSIONS: Our results, in two transgenic mouse models, suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations.  - Bio-Flex

At Osteoklinika we use Bio-Flex Laser.  For more information, Andrew Subieta and the clinic staff can be reached at Osteoklinika Pain Management & Rehabilitation 905.660.8810.  Also, please check our website www.osteoklinika.com for more information about Bio-Structural Integration™ at Osteoklinika!